Composition
Cerviron has a substance content that gives it beneficial properties in multiple conditions of non-infectious vulvovaginitis and cervical erosions. The ovule melts in the vaginal mucosa forming a cream that ensures even dispersion of the substances contained and acts as a protective barrier with astringent effect, favoring the reepithelialization of damaged tissue and the restoration of the initial colpoecosystem without affecting the Döderlein bacilli.
Each ovule contains: bismuth subgallate – 100mg, vegetable collagen- 15mg. Excipients: thyme extract (Thymus vulgaris), goldenseal extract (Hydrastis canadensis), calendula extract (Calendula officinalis), turmeric extract (Curcuma longa), hexylresorcinol, semisynthetic glycerides, anhydrous lanolin, colloidal silicon dioxide.
Bismuth subgallate
Bismuth subgallate has local astringent action, an action which can facilitate both its deodorizing and haemostatic effects. The compound forms a protective barrier in the vaginal mucosa which prevents the adhesion of pathogenic bacteria to the vaginal mucosa and promotes natural healing of damaged tissue.
The action of bismuth compounds takes place at the site of administration by sealing the damaged tissue, as bismuth subgallate is biocompatible with healing tissue and did not interfere with the normal development of wound healing.
In the medical device, bismuth subgallate powder is used, due to its astringent effect, to create a physical barrier over the affected area of the vaginal mucosa and therefore to prevent oxygen and pathogens from coming into contact with it. In this way, the substance creates the premises that allow the damaged tissue to heal naturally and prevents the development of pathogenic bacteria favoring the restoration of normal vaginal flora.
Hydrolyzed vegetable collagen
Hydrolyzed vegetable collagen is the main component of living tissues being a complex of amino acids, with nourishing, moisturizing, healing, trophic effect. Topically applied collagen forms extracellular matrices that promote natural immune processes and reepithelialization of damaged tissue.
In vitro, natural collagen can be made up of highly organized three-dimensional scaffolds that are biocompatible, biodegradable, non-toxic to exogenous application and have high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications.
Vegetable collagen supports a moist environment, conducive to wound healing, encourages the deposition of new collagen fibers, supports the growth of new tissues and the formation of granulation tissue in the wound bed. A key component of chronic wounds is an elevated level of matrix metalloproteinases (MMPs). At high levels, MMP not only degrades non-viable collagen, but also viable collagen. In addition, fibroblasts in a chronic wound cannot secrete tissue MMP inhibitors (TIMPs) at an adequate level to control MMP activity. These events prevent the formation of scaffolds needed for cell migration and ultimately prevent the formation of the extracellular matrix (ECM) and tissue granulation. The exogenous action of collagen acts as a “sacrificial substrate” in the wound. Collagen degradation products have also been shown to be chemotactic for a variety of cell types required for granulation tissue formation.
Taking into account the data from the specialized literature, vegetable collagen, applied locally in the case of wounds, maintains the level of moisture at the level of the wound, favoring its healing. At the same time, the supply of exogenous vegetable collagen acts as a sacrificial substrate that favors the natural healing of the damaged tissue.
