CERVIRON in the treatment of vaginitis

CERVIRON in the treatment of vaginitis

The benefits of Cerviron® in the treatment of atrophic, aerobic, and traumatic vaginitis

In the treatment of atrophic, aerobic, and traumatic vaginitis, the specialist gynaecologist will prescribe the background treatment, which will generally be given for 10 days to 3 weeks, depending on the severity of the symptoms or the severity of the infection. Maintenance therapy can be applied for 2-6 months to avoid reinfection. These treatments aim to reduce inflammation, maintain a healthy vaginal microflora, and prevent relapses.
The application of vaginal preparations that have in their composition elements with the role of protection and regeneration of vaginal microflora are therefore very indicated both as adjuvants in acute or chronic vulvovaginitis and to prevent relapses. Effective treatment should include antibacterial, but also anti-inflammatory, healing, and antifungal substances.
Cerviron® is an ovule-shaped medical device with local therapeutic action, indicated in the adjuvant therapy of atrophic, aerobic, and traumatic vaginitis.
Cerviron® has 7 active principles with beneficial effects for a targeted action in the treatment of acute and chronic vulvovaginitis of aerobic, atrophic, or mechanical aetiology, caused by changes in vaginal pH or by changes in the vaginal microbiota. These properties are due to the cumulative effects of its active compounds. The low concentrations in which the active compounds are found avoid possible unwanted local effects, restoring the original vaginal ecosystem. The beneficial effects are based on the therapeutic action of 4 medicinal plants, as well as on the topical action of 3 other compounds (hexylresorcinol, collagen, and bismuth subgallate).

Therapeutic action of the seven principles of Cerviron® in atrophic, aerobic, and traumatic vaginitis


Bismuth subgallate acts favourably in the treatment of lesions or ulcers occurring in more severe forms of vaginitis, through its effect of haemostasis. The bismuth subgallate has an astringent role, forming a protective barrier at the level of the vaginal mucosa, which does not allow the entry of pathogens.
Thus, Cerviron® favours the processes of scarring and reepithelization, restores the vaginal microbiota, reduces the proliferation of endogenous pathogens, and reduces the symptoms and discomfort associated with vulvovaginitis. In the long run, Cerviron® prevents relapses and contributes to maintaining a healthy vaginal flora.


If untreated, inflammation can have unintended long-term consequences, leading to chronic wounding and thickening of tissues.
Marigold extract is perhaps the most common natural remedy for the treatment of mild lesions of the skin and mucous membranes, favouring healing by reducing inflammation. By reducing inflammation, Marigold extract promotes the reduction of discomfort, pain, and irritation.
The anti-inflammatory properties are due to compounds in the plant that reduce the infiltration of white blood cells, thereby aiding in the formation of granulation tissue.

Figure 2. Marigold extract double action
Figure 2. Marigold extract double action

Marigold extract is recommended by the European Group of Scientific Cooperation in Phytotherapy (ESCOP) for the treatment of inflammations of the skin and mucous membranes, but also to promote reepithelialisation, cellular and tissue regeneration. Marigold preparations have also been approved by the European Medicines Agency (EMA) for the treatment of inflammation and light injuries. 

Tissue regeneration is very important in vulvovaginal infections because the fissured mucosa allows the migration of other microbes and favours the overlapping of a new infection. 

Marigold extract is used successfully to heal lesions and in various other invasive gynaecological procedures, such as biopsy or electrocautery loop.


In the Monograph dedicated to medicinal plants with therapeutic effect, published by the World Health Organization, it is recommended to use dried roots and rhizomes of Goldenseal for the treatment of various diseases of the urinary apparatus, such as in the treatment of urinary infections (cystitis), dysmenorrhea, uterine haemorrhage, inflammation, and vaginitis. Gentian contains compounds called berberines, hydrastines and canadines, with antimicrobial effect.  Furthermore, Berberine sulphate inhibits the growth and development of various bacteria and protozoa, such as Entamoeba histolytica, Giardia lamblia, Gardnerella vaginalis and Trichomonas vaginalis. (15) Berberine also has a well-known effect in reducing clinical symptoms and healing inflammatory or bacterial vaginitis. 

Figure 3. Trichomonas vaginalis after 24-hour exposure to Berberine. The autophagic white vacuoles destroy the cellular cytoplasm of Trichomonas vaginalis.

Therefore, Cerviron®, consisting of dry Gentian extract, is particularly indicated in the adjuvant treatment of vaginitis, especially for patients who have relapsed or who have developed resistance to antibiotic treatment.


Thyme is used in topical preparations for beneficial effects in reducing microbial activity and for a slight anti-inflammatory effect. Thyme reduces the migration of microbes and bacteria to the urethra and rectum and is safe to use in pregnancy. 
Thymol and other volatile oils in thyme extract (linalool, alpha-pinene) have a disinfectant role. Bacteria such as Escherichia coli, Klebsiella pneumoniaea, Yersinia enterolitica, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis are sensitive to the antiseptic action of thyme ethanolic extract. (18) In addition, thymol also has an anti-inflammatory effect, which is manifested by the reduction of the effects of free radicals but also by the action on the mediators of inflammation.
Cerviron®, having in its composition thyme glycolic extract, prevents bacteria migration and has a beneficial anti-inflammatory effect, reducing the pain and discomfort associated with vaginitis.


Turmeric extract is used for the anti-inflammatory and antioxidant effects of curcumin in the composition, especially curcumin. Curcumin is a powerful natural anti-inflammatory, with the effect of reducing local inflammation and discomfort associated with vulvovaginitis.
A recent study compared the effects of Turmeric with Clotrimazole vaginal cream in treating vulvovaginitis. The group of patients comprised 96 women aged between 18-45 years. The results showed a similar action of Turmeric compared to clotrimazole in reducing leucorrhoea, local itching, vulvovaginal irritation and vulvovaginal erythema. 
The anti-inflammatory effect is complemented by the antibacterial action of Turmeric, which thus prevents reinfection with a new bacterial infection. Therefore, Turmeric is more effective in fighting mixed infections compared to synthetic therapy (azoles). 
In addition, Turmeric increases the antioxidant capacity of the body. The antioxidants in Turmeric destroy free radicals and thus protect against oxidative stress.
Cerviron®, through the Turmeric glycolic extract, helps reduce vaginal secretion, associated itching, vulvovaginal irritation and unpleasant vulvovaginal erythema, increases the local and systemic antioxidant capacity, and prevents reinfection with another microbe.


Collagen is a natural protein, specific to the skin, which is part of the extracellular matrix, having an important role in the structure and functions of the skin. The extracellular matrix made up of the collagen triple helix retains water and thus helps to maintain a smooth, fine, and healthy skin structure. With age, the production of collagen fibres begins to decrease, and the skin loses its elasticity and shape.

Vegetable collagen supports a moist environment, favourable to wound healing, stimulates the deposition of new collagen fibres, supports the formation of granular tissue. Collagen in hydrolysed form is highly soluble, and easily absorbable, reaching deep layers where it significantly improves skin parameters. Collagen, added to topical vaginal preparations, has a synergistic and potentiating effect in reducing clinical symptoms from vaginitis, especially vaginal dryness, associated vulvovaginal irritation, dyspareunia and dysuria. 

The vegetable collagen in the Cerviron® ovules promotes healing and reepithelization by nutritional, hydrating and trophic effect. Thus, Cerviron®, through the collagen hydrolysate in the composition, has a beneficial effect in preventing vaginal dryness and irritation, having an excellent compatibility with the skin and the vaginal mucosa, and being absorbed into the deep layers of the skin, where it favours hydration.


The decreasing efficiency of antibiotic treatments due to pathogens that have become resistant is a great challenge in clinical practice. With the development of antimicrobial resistance, there is a risk that common infections will recur. A new approach to this undesirable phenomenon is the search for adjuvant substances, which can enhance the antimicrobial activity of widely used antibiotic treatments.
Hexylresorcinol is an organic compound with antimicrobial, anaesthetic, antiseptic and anthelmintic effects. Indeed, alkylresorcinols were tested with favourable results, in combination with 12 clinically used antibiotics. (23) The antimicrobial action of hexylresorcinol is due to the easy degradation of proteins produced by bacteria.
Thus, Cerviron®, by the hexylresorcinol in the composition is indicated as an adjunct treatment for both to increase the effectiveness of antibiotic or antimycotic treatments and to minimize antimicrobial resistance. By minimizing the risk of developing antimicrobial resistance, the indirect benefits are the following: shortening the treatment period, reducing the costs associated with consecutive treatment schemes and complications.